Summary information on specimens, neuropathology, and quantification of protein and isoprostane

The following information is available for download in tabular form as comma-separated values (csv) files:

• De-identified clinical information (including Alzheimer’s disease, dementia, and TBI diagnoses) for all donors included in the study.
• Values for Luminex protein quantification, isoprostane quantification and immunohistochemistry pathology metrics for tissue specimens.
• Brief description of stains used and values provided in the files listed above.

RNA sequencing data

RNA sequencing datasets from 107 brains, including 377 samples from cortical grey (parietal and temporal) and white matter (parietal) and hippocampus.

The following files enable in-depth analysis of the available RNA-Seq data:

• Both normalized (as displayed in the RNA-Seq page heatmap) and unnormalized gene-level FPKM values for all samples. (zip)
• URLs to data files for each sample, including un-normalized gene-level FPKM and TPM values, bigWig files for transcriptome aligned data and anonymized BAM files for all aligned data. (csv)
• Reference genome .gtf file used to process the RNA-Seq data. (zip)
• Raw data (FASTQ) and the output files after alignment (bam/FASTQ) are available for controlled access through NIAGADS

Supplemental data

• Subject and sampling weights calculated as described in the Weighted Analyses document. (csv)